A plan to replicate Mark Davis’s remarkable findings of immune activation in ME/CFS

A team led by Edinburgh University’s Professor Chris Ponting has won funding for a PhD student who would follow up and expand on remarkable recent findings made at Stanford University, where Dr Mark Davis may have pinpointed a major issue in the immune system in ME/CFS. Last year, Davis produced strong evidence of T cell … Read moreA plan to replicate Mark Davis’s remarkable findings of immune activation in ME/CFS

There’s a yawning gap in ME/CFS research funding. Take action.

When I got ME more than 20 years ago, I thought that science would soon provide the answers to my illness. Instead, I saw little good research going on, and there’s been a spectacular lack of progress since then. We have no treatments and still don’t even know what causes the disease. Why not? The … Read moreThere’s a yawning gap in ME/CFS research funding. Take action.

A new research landscape emerges in America

collaboratives map

Things are changing in the US for ME/CFS research as four new collaboratives set up and get to work. In September last year, the National Institutes of Health (NIH) announced $35 million of funding to establish three new ME/CFS research collaboratives and a supporting data centre. Since then, the Open Medicine Foundation (OMF) has helped … Read moreA new research landscape emerges in America

The CMRC embraces the biomedical

The CFS/ME Research Collaborative has belatedly recognised the critical importance of focusing on biomedical research to uncover the biological mechanisms behind ME/CFS. Its controversial deputy chair, Prof Esther Crawley, is standing down and will be replaced by biomedical researcher Prof Chris Ponting. The Collaborative has started taking concrete action to engage with patients and has also announced ambitious plans to enable much more biomedical research in the UK. [read more]

PACE trial’s findings fundamentally challenged by a new study

In a nutshell: Analysing PACE the way the authors originally promised to do showed that CBT and GET didn’t do much to improve self-reported physical function and fatigue and did not lead to recovery. Even the very limited self-reported gains in this unblinded trial are likely to be illusory because they are not backed up by meaningful gains in objective measures, such as fitness. The self-report gains also appear not to last. We now need biomedical research to pave the way for effective treatments.

Researchers and patients have been pointing out problems with the PACE trial for years. A new paper goes further by reanalysing the raw data to give the results the way the trial authors originally said they would give them, before they opted for softer measures of success. The new paper, published in the journal BMC Psychology, also sets out all the flaws of the PACE trial in one place.

Rethinking the treatment of chronic fatigue syndrome—A reanalysis and evaluation of findings from a recent major trial of graded exercise and CBT

Carolyn E. Wilshire, Tom Kindlon, Robert Courtney, Alem Matthees, David Tuller, Keith Geraghty and Bruce Levin

carolyn-wilshire photo
Dr Carolyn Wilshire

It comes from a team that was led by research psychologist Dr Carolyn Wilshire and included a professor of biostatistics and several researcher-patients, each of whom has a string of publications to their name. Alem Matthees, whose long Freedom of Information battle with the PACE authors secured the release of the underlying data, is among the co-authors.

The new work, using the original analysis method published in the study protocol, revealed results that are much less impressive than the ones published by the PACE authors.

How PACE’s results really looked

Read morePACE trial’s findings fundamentally challenged by a new study

Welcome to the ME/CFS Research Review

Welcome to the ME/CFS Research Review blog, which aims to explain the most promising biomedical findings — and ignore pretty much everything else. So there will be occasional, in-depth blogs explaining the science in the studies, and what the findings mean. I’m Simon McGrath and I’m a bit of a science nerd. A long time … Read moreWelcome to the ME/CFS Research Review

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